What is Methadone
Do you know what is methadone? It is chemically described as 6-(dimethylamino)-4,4-diphenyl-3-heptanone hydrochloride. It is a white, crystalline material that is water-soluble. This has a melting point of 235°C, and a pKa of 8.25 in water at 20°C. Its octanol/water partition coefficient at pH 7.4 is 117. A solution (1:100) in water has a pH between 4.5 and 6.5.
These Oral Tablets each contain 5 or 10 mg of methadone hydrochloride, USP, and the following inactive ingredients: dibasic calcium phosphate, microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide, pregelatinized starch, and also stearic acid.
Methadone hydrochloride Oral Tablets, USP are indicated for the:
-Management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.
-Detoxification treatment of opioid addiction (heroin or other morphine-like drugs).
-Maintenance treatment of opioid addiction (heroin or other morphine-like drugs), in conjunction with appropriate social and also medical services.
Limitations of Use
Methadone is not for use:
-As an as-needed (prn) analgesic
-For pain that is mild or not expected to persist for an extended period of time
– Indicate for acute pain, also
-For postoperative pain
Initial Dosing for Management of Pain:
Consider the following factors when selecting an initial dose of Methadone:
-Total daily dose, potency, and prior opioid the patient has been taking previously;
-Patient’s degree of opioid experience and also opioid tolerance;
-General condition and also medical status of the patient;
-Concurrent medication, also
-Type and severity of the patient’s pain
Dosage Forms And Strengths
These Oral Tablets (methadone hydrochloride tablets USP) are available in 10 mg dosage strengths. The 10 mg tablets are white, also scored tablets.
Storage And Handling
It contains methadone which is a controlled substance. Like fentanyl, morphine, oxycodone, hydromorphone, and
oxymorphone are controlled under Schedule II of the Federal Controlled Substances Act. Methadose may be targeted for theft and also diversion by criminals [see WARNINGS AND PRECAUTIONS].
Keep tightly closed. Dispense in a tight, light-resistant container.
Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].
As Oral Tablets:
10 mg white, scored tablets (Identified METHADOSE 10)
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